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Hemodynamics

Mortality

Renal Implications

Background Problem

Prominent practice guidelines currently recommend IV albumin administration for the treatment of  sepsis-related hypotension. This practice is commonly seen in the anesthesia world in middle Tennessee. However, the endothelial dysfunction related to glycocalyx alterations of sepsis pathophysiology allows for albumin transcapillary leakage. This effect can theoretically result in both worsened interstitial edema, as well as worsened intravascular depletion after albumin administration.

Consideration 1:

Does albumin have a  hemodynamic benefit in sepsis patients?

Consideration 2:

Is there a mortality benefit fueling the recommendation of albumin in sepsis patients?

Consideration 3:

What is the effect on end organ perfusion associated with albumin vs crystalloid in sepsis patients?

Who we are:

We are a group of SRNAs at MTSA with a compelling question we used to design this educational project

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Brett Clay DNAP CRNA

Project Chair

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John Brown

Time Manager

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Amy Glass

Group Liaison

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S. Taylor Knight

Group Leader

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Levi Primasing

Scribe

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Jay Warren

Editor

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