Albumin Administration in the Septic Patient
Hemodynamics
Mortality
Renal Implications
Background Problem
Prominent practice guidelines currently recommend IV albumin administration for the treatment of sepsis-related hypotension. This practice is commonly seen in the anesthesia world in middle Tennessee. However, the endothelial dysfunction related to glycocalyx alterations of sepsis pathophysiology allows for albumin transcapillary leakage. This effect can theoretically result in both worsened interstitial edema, as well as worsened intravascular depletion after albumin administration.
Consideration 1:
Does albumin have a hemodynamic benefit in sepsis patients?
Consideration 2:
Is there a mortality benefit fueling the recommendation of albumin in sepsis patients?
Consideration 3:
What is the effect on end organ perfusion associated with albumin vs crystalloid in sepsis patients?
Who we are:
We are a group of SRNAs at MTSA with a compelling question we used to design this educational project
Brett Clay DNAP CRNA
Project Chair
